The illness of cancer operates beyond the physical engagements of sick children, influencing their other dimensions of health, particularly spiritual well-being, and in this process, it gives rise to unique spiritual challenges. The nature of the concept of ‘God’ and the manner of establishing a connection with Him constitute one of the primary spiritual concerns for this group of children, serving as a decisive factor in shaping their spiritual health trajectory and their Post-Traumatic Growth process. Accordingly, this research, relying on an Interpretive Phenomenological Analysis method, after outlining the framework of the children’s spiritual worldview and their lived spiritual experience, examines the theistic concepts of 30 hospitalized children with cancer at Seyed al-Shohada Hospital in Isfahan Province. The findings indicate that their understanding of the divine concept can be categorized into five main classifications: Magical God, Trading God, Veiling God, Controlling God, and Meaning-Bestowing God. The manner in which each of these theistic models is perceived has a profound impact on the structure of these patients’ spiritual worldview; it can act both as a facilitator for spiritual growth and transcendence and the enhancement of spiritual well-being, and simultaneously expose them to serious spiritual conflicts and traumas