Depression is one of the psychological disorders that can be affected by a person's perception of themselves as a human being. The aim of the present study was to investigate the anthropological perspective of girls with depression. For this purpose, purposive sampling was initiated among women referring to counseling centers in Rasht in 1401 who had a history of depression according to the DSM diagnosis and continued until theoretical saturation. A total of 16 girls with a history of depression were selected and interviewed in a semi-structured manner and finally analyzed using a qualitative content analysis method. The findings showed that the anthropological perspective centered around six main categories of human nature, the purpose of life, the end of life (with subcategories of death, reaching the goal, and blackness), the source of human worth (with subcategories of attracting the attention of others, beautiful appearance, personal feeling), the criterion of action, and the origin of human existence (beginning) (with subcategories of God, evolution, and marriage). Special attention to the discovered categories, such as the source of worth and purpose of life, allows clinicians to penetrate the underlying layers of negative automatic thoughts and to bring therapy into the realm of meaning and identity. Accordingly, it is suggested that "anthropological narrative reconstruction" be taken as a complementary and powerful component in intervention packages for serious depression. Such an approach elevates the treatment of depression from the level of cognitive modification to the level of existential paradigm shift.